2021


Zha S, Shao Z, Zhu Y. The plié by DNA-PK: dancing on DNA.  Mol Cell. 2021 Feb 18;81(4):644-646. doi: 10.1016/j.molcel.2021.01.025. PMID: 33606972


Milanovic M, Shao Z, Estes VM, Wang XS, Menolfi D, Lin X, Lee BJ, Xu J, Cupo OM, Wang D, Zha S.FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis. J Immunol. 2021 Feb 3:ji2000967. doi: 10.4049/jimmunol.2000967. Online ahead of print.PMID: 33536256
 

2020

Milanovic M, Houghton LM, Menolfi D, Lee JH, Yamamoto K, Li Y, Lee BJ, Xu J, Estes VM, Wang D, McKinnon PJ, Paull TT, Zha S#. The cancer-associated ATM R3008H mutation reveals the link between ATM activation and its exchange. Cancer Res. 2020 Nov 25:canres.2447.2020. doi: 10.1158/0008-5472.CAN-20-2447. Online ahead of print. PMID: 33239428

 

Wang XS, Zhao J, Wu-Baer F, Shao Z, Lee BJ, Cupo O, Rabadan R, Gautier J, Baer R, Zha S#. CtIP mediated end-resection is dispensable for alternative end-joining mediated class switch recombination. Proc Natl Acad Sci U S A.  Oct 13;117(41):25700-25711. doi: 10.1073/pnas.2010972117. Epub 2020 Sep 28. PMID: 32989150  

 

Shao Z, Lee BJ, Rouleau-Turcotte E, Langelier M, Estes VM, Lin X., Pascal JM, Zha S#. Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo. Nucleic Acid Research 2020 Sep 25;48(17):9694-9709. doi: 10.1093/nar/gkaa718. PMID: 32890402

 

Crowe JL*, Wang XS*, Shao Z, Lee BJ, Zha S#. DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A.  2020 Aug 31:202007455. doi: 10.1073/pnas.2007455117. Online ahead of print. PMID: 32868446; the earlier version available at biorxiv https://www.biorxiv.org/content/10.1101/2020.04.23.057877v1

Wang X, Lee BJ, Zha S# The recent advances in non-homologous end-joining through the lens of lymphocyte development. DNA Repair 2020 Jun 25;94:102874. doi: 10.1016/j.dnarep.2020.102874. Online ahead of print. PMID: 32623318

Tao Y, Li M, Liu X, Leong KW, Gautier J and Zha S#. Dual-color plasmonic nanosensor for radiation dosimetry. ACS Applied Materials & Interfaces 2020 May 7. doi: 10.1021/acsami.0c03001. PMID: 32337977

 

Liu X, Liu T, Shang Y, Dai P, Zhang W, Lee BJ, Huang M, Yang D, Wu Q, Liu DL, Zhou BO, Dong J, Yeap L, Hu J, Xiao T, Zha S, Casellas R, Liu XS, Meng F. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Cell Research 2020 Apr 30. doi:10/1038/s41422-020-03283. PMID:32355287

 

Shao Z*, Flynn RA*, Crowe JL*, Zhu Y, Liang J, Jiang W, Aryan F, Aoude P, Bertozzi CR, Estes VM, Lee BJ, Bhagat G, Zha S#, Calo E# DNA-PKcs has KU dependent function in ribosomal RNA processing and hematopoiesis Nature 2020 Mar;579(7798):291-296. doi: 10.1038/s41586-020-2041-2. Epub 2020 Feb 26. PMID: 32103174

Also see News and Views by Dr. Alan Warren 

Menolfi D, Zha S.# ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition ≠ deletion. Cell Biosci. 2020 Jan 29;10:8. doi: 10.1186/s13578-020-0376-x. eCollection 2020. Review. PMID: 32015826

2019

Scuoppo C, Zha S#. LMO2 as a biomarker for hypersensitivity to genotoxic therapy. Cancer Cell 2019 Sep 16;36(3):211-212 PMID: 31526755


Menolfi D and Zha. S# ATM, DNA-PKcs and ATR: shaping development through the regulation of the DNA Damage Responses. The inaugural issue of Genome Instability & Disease 2019 May 20. Published online 

 

Jiang W, Estes VM, Wang XS, Shao, Z Lee BJ, Lin X, Crowe JL and Zha S#. Phosphorylation at the S2056 cluster of DNA-PKcs is dispensable for lymphocyte development and class switch recombination in mice. Journal of Immunology 2019 May 17. pii: ji1801657. doi: 10.4049/jimmunol.1801657. [Epub ahead of print] PMID: 31101667

 

Liu X*, Wang XS*,  Lee B.J., Wu-Baer FK, Lin X, Shao S, Estes VM, Gautier J, Baer RJ, and Zha S#. CtIP is essential for early B cell proliferation and development in mice. J Exp Med. 2019 May 16. pii: jem.20181139. doi: 10.1084/jem.20181139. [Epub ahead of print] PMID: 31097467

 

Nicolas L, Cols M, Smolkin R, Fernandez K, Yewdell WT, Yen Y, Zha S, Vuong BQ and Chaudhuri J. ATM influences germinal center integrity. Journal of Immunology 2019 Apr 26. pii: ji1801033. doi: 10.4049/jimmunol.1801033. [Epub ahead of print] PMID: 31028119
 

2018

Menolfi, D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S#. ATR inhibition differs from ATR loss by limiting the dynamic exchange of ATR and RPA on ssDNA filaments. Nature Communication 2018 Dec 17;9(1):5351. doi: 10.1038/s41467-018-07798-3. PMID: 30559436


Zeeuw C, Barzilai A, Alfo M, Zha S, Ziv Y, Tal E, Shiloh Y Inactive Atm abrogates DSB repair in mouse cerebellum more than does Atm loss, without causing a neurological phenotype DNA repair (Amst). 2018 Dec;72:10-17. doi: 10.1016/j.dnarep.2018.10.001. Epub 2018 Oct 11. PMID: 30348496
 

Billing D, Horiguchi M, Wu-Baer F, Taglialatela A, Leuzzi G, Nanez SA, Jiang W, Zha S, Szabolcs M, Lin CS, Ciccia A, Baer R. The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection. Mol Cell. 2018 Oct 4;72(1):127-139.e8. doi: 10.1016/j.molcel.2018.08.016. Epub 2018 Sep 20. PMID: 30244837
 

Crowe JL*, Shao Z*, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S#. Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8615-8620. doi: 10.1073/pnas.1808490115. Epub 2018 Aug 2.PMID: 30072430 PMID:30072430

Hung PJ, Johnson B, Byrum A, Bredemeyer AL, Yewdell W, Johnson TE, Lee BJ, Deivasigamani S, Paull TT, Pisapia D, Chadhury D, Mosammaparast N, Amarasinghe GK, Zha S, Tyler JK and Sleckman BP MRI is a DNA Damage Response Adaptor during Classical Non-Homologous End Joining Mol Cell. 2018 Jul 19;71(2):332-342. PMID: 30017584
 

Schrader, G. Crispatzu, S. Oberbeck, P. Mayer, S. Pützer, J. von Jan, E. Vasyutina, K. Warner, N. Weit, N. Pflug, T. Braun, E.I. Andersson, B. Yadav, A. Riabinska, B. Maurer,M. S. Ventura Ferreira, F. Beier, J. Altmüller, M. Lanasa, C.D. Herling1, T. Haferlach, S. Stilgenbaue, G. Hopfinger, M. Peifer, T.H. Brümmendorf, P. Nürnberg, K.S.J. Elenitoba-Johnson, S. Zha, M. Hallek, R. Moriggl, H.C. Reinhardt, M.-H. Stern, S. Mustjoki, S. Newrzela, P. Frommolt & M. Herling Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL A. Nat. Commun. 2018 Feb 15;9(1):697. doi: 10.1038/s41467-017-02688-6. PMID: 29449575

2017

Roohi J. Crowe J, Loredan D, Anyane-Yeboa K, Mansukhani MM, Omesi L, Levin J, Politi AR, Zha S#. New Diagnosis of Atypical Ataxia-Telangiectasia in a 17-Year-Old Boy with T-Cell Acute Lymphoblastic Leukemia and a Novel ATM mutation. J Hum Genet. 2017 Jan 26. PMID: 28123174

 

Liu X, Shao Z, Jiang W, Lee BJ, Zha S#. PAXX promotes Ku-accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.  Nat. Commun. 2017 Jan 4;8:13816. PMID: 28051062

 

Zhou Y, Lee J, Jiang W, Crowe JL, Zha S, Paull TT. Regulation of the DNA damage response by DNA-PKcs inhibitory phosphorylation of ATM. Molecular Cell 2017 Jan 5;65(1):91-104. PMID: 27939942

2016

Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S. Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors. Elife. 2016 Jun 15;5. PMID: 27304073

Li T, Liu X, Jiang L, Manfredi J, Zha S, and Gu W. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget 2016 Mar 15;7(11):11838-49. PMID: 26943586

2015

Pinkey KA*, Jiang W*, Lee BJ, Loredan DG, Li C, Bhagat G and Zha S. Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas. Journal of Hematology & Oncology 2015 Jul 30;8:94. PMID: 26219558

Yamamoto K, Lee BJ, Li C, Dubois RL, Hobeika E, Bhagat G, Zha S. Early B-cell Specific Inactivation of ATM Synergizes with Ectopic CyclinD1 Expression to Promote Pre-germinal center B-cell Lymphomas in Mice. Leukemia. 2015 Jun;29(6):1414-24. PMID: 25676421

Jiang W, Lee BJ, Li C, Dubois R.L, Gostissa M, Alt FW and Zha S. Aberrant TCRδ rearrangement underlies the T cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. 2015 Apr 23;125(17):2665-8. PMID: 25721125.

Jiang W*, Crowe J*, Liu X*, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S. Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during non-homologous end-joining. Molecular Cell 2015 Apr 2;58(1):172-85 PMID:25818648

Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, Zha S, Lan L, Liang H, Xu D. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun. 2015 Feb 11;6:6233. PMID: 25670504

2014 and Before

Avagyan S, Churchill M, Yamamoto K, Crowe JL, Li C, Lee BJ, Zheng T, Mukherjee S, Zha S. Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency. Blood 2014 Sep 4;124(10):1622-5. PMID: 25075129

Moding EJ, Lee CL, Castle KD, Oh P, Mao L, Zha S, Min HD, Ma Y, Das S, Kirsch DG. Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. J Clin Invest. 2014 Aug 1;124(8):3325-38. PMID: 25036710

Yamamoto K, Wang Y, Jiang W, Dubois RL, Ludwig T, Lin C, Bakkenist CJ., Zha S. Kinase-Dead ATM protein causes genomic instability and early embryonic lethality in mice. Journal of Cell Biology 2012 Aug 6;198(3):305-13 PMID: 22869596

Liu X, Zha S. ATMIN: a new tumor suppressor in developing B cells. Cancer Cell. 2011 May 17;19(5):569-70. doi: 10.1016/j.ccr.2011.05.002. PMID:21575856

Liu X, Jiang W, Dubois RL, Yamamoto K, Wolner Z, Zha S. Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development. Proc Natl Acad Sci U S A. 2012 Mar 6;109 (10):3903-8. PMID:22413262

Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5):2028-33. PMID: 21245310

Zha S*, Guo C*, Boboila C, Oksenych V, Cheng H, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff  PH, Dubois RL and Alt FW. XLF Has Functional Redundancy with ATM and H2AX in Non-homologous DNA End-joining. Nature 2011 Jan 13; 469(7329):250-4. PMID:21160472

Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Gatti R, Look AT, Alt FW. ATM-Deficient Thymic Lymphoma Is Associated With Aberrant TCRd Rearrangement And Gene Amplification. J Exp Med. 2010 Jul 5;207(7):1369-80. PMID: 20566716

Li G*, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S*. Lymphocyte-Specific Compensation For XLF/Cernunnos End-Joining Functions In V(D)J Recombination. Mol. Cell. 2008 Sept.5;31(5):631-40. PMID:18775323

Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9302-6. PMID:18599436

Zha S, Alt FW, Cheng HL, Brush JW, Li G. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4518-23. PMID:17360556